Genome-Wide Association Study in 3,173 Outbred Rats for Body Weight, Adiposity, and Fasting Glucose.
This study identified 32 independent loci, several of which contained only a single gene (e.g., Epha5, Nrg1, Klhl14) or obvious candidate genes (e.g., Adcy3, Prlhr). There were strong phenotypic and genetic correlations among obesity-related traits, and there was extensive pleiotropy at individual loci.
P50 DA037844 R01 DK106386
Methods for genotype
Genotypes were determined using genotyping-by-sequencing (GBS), as described previously (Parker et al (2016)).
Methods for Phenotypes
body length from nose to end of the tail, and from nose to the base of the tail
body mass index body weight divided by the square of the body length, fasting glucose
retroperitoneal fat pad weight
epididymal fat pad weight for males
parametrial fat pad weigh for females
Methods for Omics