Findable, Accessible, Interoperable, Reusable data generated by the NIDA center for genetic studies of drug abuse in outbred rats.
Publication name and date | Genotypes | Phenotypes | Omics Data | Sample size | Dataset access |
---|---|---|---|---|---|
Gunturkun et al., Genome-Wide Association Study on Three Behaviors Tested in an Open Field in Heterogeneous Stock Rats Identifies Multiple Loci Implicated in Psychiatric Disorders. Front Psychiatry. 2022 Feb 14;13:790566. doi: 10.3389/fpsyt.2022.790566. PMID: 35237186; PMCID: PMC8882588. 2022 |
3,513,494 Version R8 |
Locomotion
Novel Object
Interaction
+1
|
None |
1246
|
More details |
U01: Genetic Basis of Opioid Dependence Vulnerablility (U01DA045300) 9/30/2018 |
4,609,405, version R9 |
self- administration
drug-seeking
|
RNA-Seq |
Goal: 1000 Current: 655
|
More details |
U01: Genomic analysis of avoidance learning in addiction (U01DA044468) 4/15/2018 |
4,609,405, version R9 |
Avoidance-Learning
|
RNA-Seq |
Goal: 1200 Current: 1239
|
More details |
U01: Genetics of Compulsive Cocaine Intake in Rats (U01DA043799) 4/1/2017 |
4,609,405, version R9 |
Addiction Index
Aggression Behavior
Defensive Behavior
+2
|
None |
Goal: 1000 Current: 882
|
More details |
U01: Genetics of Compulsive Oxycodone Intake in HS Rats (U01DA044451) 8/13/2019 |
4,609,405, version R9 |
Oxycodone infusions
Reward intake
Tail immersion
+1
|
None |
Goal: 1000 Current: 619
|
More details |
R01: Identification of Genes Regulating Bone Matrix Composition and Quality 9/15/2016 |
None |
Bone density
|
None |
Goal = 4800
|
More details |
U01:Characterization of Tandem Repeat and Structural Variants Contributing to Addictive Behaviors in Mice and Rats Not available |
4,609,405, version R9 | None |
None
|
More details | |
U01: Decoding the grammar of transcriptional enhancers regulating different stages of opioid use disorder 9/30/2020 |
4,609,405, version R9 |
RNA-Seq
ATAC-seq
|
RNA-Seq |
None
|
More details |
Genetic basis for unilateral renal agenesis in heterogenous stock rats TBD |
Version R8 |
Unilateral renal agenesis
|
None |
5585
|
More details |
Structural equation modeling for understanding the genetic architecture of cocaine contextual conditioning and cocaine conditioned cue preference in heterogeneous stock rats undercover candidate genes for behavioral variation caused by cocaine exposure TBD |
Version R8 |
Cocaine contextual conditioning
cocaine conditioned cue preference
|
3050
|
More details | |
Genetic architecture for cecum metabolomics of heterogeneous stock rats undercover candidate genes for metabolome abundance and presence TBD |
Version R8 |
Cocaine Contextual Conditioning
Cocaine Conditioned cue Preference
|
Metabolomics |
1000
|
More details |
Chitre AS et al. Genome-Wide Association Study in 3,173 Outbred Rats Identifies Multiple Loci for Body Weight, Adiposity, and Fasting Glucose. Obesity (Silver Spring). 2020 Oct;28(10):1964-1973. doi: 10.1002/oby.22927. Epub 2020 AUG 29. PMID: 32860487; PMCID: PMC7511439. 2022 |
3,400,759 SNPs Version 2018 |
Body length with no tail
body length with tail
body weight
+5
|
None |
3173
|
UCSD library |
P50 Project 1: Neurogenetic Substrates of Cocaine Addiction 2019-2024 |
4,609,405, version R9 |
Intermittent access to cocaine
|
RNA-Seq |
Goal: 1600 Current: 1911
|
More details |
P50 Project 2: Socially-acquired nicotine self-administration |
4,609,405, Version R9 |
Open Field
Novel Object Interaction Test
Nicotine self-administration
+1
|
None |
Goal: 4800 Current: 2600
|
More details |
P50 Project 3: Association between behavioral regulation and cocaine cue preference 2014-2024 |
4,609,405, version R9.1 |
Locomotor Response
Delay Discounting
Light Reinforcement
+5
|
None |
Goal: 1600 Current: 1066
|
More details |
P50 Project 4, P50: Network-based analysis 2019-2024 |
4,609,405, version R9 |
N/A
|
None |
various
|
More details |
P50 Project 1, P50: Genetic Studies of Incentive Salience 2014-2019 |
4,609,405, Version R9 |
Cocaine Contextual Conditioning
Novelty seeking
Pavlovian Conditioned Approach
|
None |
1600
|
More details |
U01: Single-cell resolution analysis of chromatin accessibility and gene expression (U01DA050239) 5/1/2020 |
4,609,405, version R9 |
RNA-Seq
ATAC-seq
H3K27Ac
+1
|
RNA-seq, ATAC-seq, H3K27Ac, PLAC-seq |
Goal: 96 Current: 96
|
More details |
U01: Genetic Features of Delay Discounting in an HS Rat Model (U01DA046077) 7/1/2018 |
4,609,405, version R9 |
Delay Discounting
impulsivity
5-choice serial reaction time task
|
RNA-Seq |
Goal: 1560 Current: 901
|
More details |
NIDA center for genetic studies of drug abuse in outbred rats (P50DA037844)
There are few effective therapies to treat drug abuse and dependence, despite the urgent need to develop more effective treatments. A major impediment to the development of such treatments is our extremely limited understanding of the biological basis of drug abuse.
While human genome-wide association studies (GWAS) have begun to elucidate genes that influence various traits relevant to drug abuse, they are still unable to attribute more than a small fraction of the heritable variance to specific genes. NIDA center for genetic studies of drug abuse in outbred rats (P50DA037844) was created in 2014 to perform GWAS on numerous behavioral traits that have well-established relevance to drug abuse using outbred rats. The Center was successfully renewed in 2019. We expect to discover new genes that can influence drug abuse-related behaviors in rats, therefore improving our understanding of genetic susceptibility to drug abuse in humans. Our results will help to identify new opportunities to treat psychiatric disorders, including addiction.
Abraham Palmer, PHD
Maryann Martone
Paul Meyer
Trey Ideker
Oksana Polesskaya
Leah Solberg-Woods
Anita Bandrowski
Hao Chen
Shelly Flagel
Jerry Richards
David Dietz
Jeffrey Grethe
Fill out the form to let us know you’re interested in using the data and please indicate which dataset(s). Once your request is submitted, we’ll review it and get in touch to send you the necessary credentials in order to access the requested dataset(s). By requesting access to the data, you agree to our license.